An amazing performance by Zoe Jackson wishing you all a very Happy Christmas

CLICK HERE TO PLAY

Filmed at Lisburn Cathedral in Northern Ireland, during 

Wallace High School's annual Christmas Concert.

No. 2 Album of 2014 for my son in law CJ...

What a way to end the year with some great news. My son in law CJ has just seen his new album voted 2nd best of 2014!!! I know he worked hard on this for many months and luckily finished it before he became a Dad, because I guess the next piece of work may take a little longer.

Best wishes to CJ and Sasha for what should prove to be a memorable year.
Can't wait to get back to the UK to see you all soon xxx

If you haven't tried CJ's Devilspit Hot Sauce yet then here's a link to the online shop...
http://cjwildheart.bigcartel.com/category/hot-sauce

It's hot on the way down and the after burn will flip you over! For real men and hairy women only! Keep locked in a safe place at all times!

How important is Facebook to you?

I think it's amazing, but I'm comparing it to a time where you had real, not just virtual friends, and the only way to keep those friends was to meet up, or at least phone regularly. I've moved on so many times that without Facebook I guess I would have no friends.

Some of my friends on Facebook, I've never met, yet enjoy the interaction with them enormously. It helped me hook up with people who I knew as far back as childhood, and even though we don't talk much after our initial contact, it's nice to see them still there. Same with old work and army colleagues, and people who I may have only met once on the other side of the world, without Facebook I would never have stayed in touch.

Having kids, it's helped me to stay in touch with what's going on in their lives as none of us are geographically close anymore. Between Facebook and Skype we have stayed tight as a family, and it's just great! Would be nice to live closer to them all one day, especially as my 3 grandchildren grow up.

I worry about the 'watchers' on Facebook, those that are friends but never, ever comment or 'like' anything you put up. I also worry about people who feel they can't use their real name, though my partner Beverley has a very good reason being a teacher. ALL her pupils would send her friends requests, and that's a bridge too far.

People sometimes lay their hearts out on Facebook, and it gives others a chance to jump in with support. I was sent a private message a while back by someone who said, "It's good to know you're always there if I need to talk Dan". Others have been there for me at desperately hard times. This can only be good, surely?

When you send someone a 'Friends Request' and they turn you down, how bad do you feel? Maybe you liked them, but they weren't as keen on you.

When someone 'de-friends' you, are you devastated? Someone did to me recently just because we disagreed on something. I dared to have a different opinion and his macho image wouldn't allow that! My favourite friends on Facebook are those who I can have a good debate with, without falling out.

When it's your birthday, do you find yourself looking closely at who sent you well wishes? Not one member of my entire family of in-laws acknowledged my birthday on Facebook this year. Should I worry that I'm not loved :-)? I always try but I must miss more than I remember. I reckon if a 3rd of your 'friends' say happy birthday, you've done well.

I laugh at people who have some +2,500 friends. In your dreams! I've got 184 and I've just counted 11 that I've never met, mainly people I've befriended on cancer support sites.

I love all the political and wildlife groups that I can keep up with on Facebook. You can also get a more balanced view of the news without the influence of the totally biased BBC, because there is stuff going on in the world right now that is simply not reported. I can follow people who I like/admire and join lobbying groups such as '38 degrees' who can influence our government, because alone, we can't. I'm even in a group called, 'Babies born at Queen Charlottes Hospital'.

Saves a fortune on birthday and christmas cards and even tells me when your birthday is. If I've got news to tell, you all get to hear at the same time. If you talk about things like cats, soaps or put photos of your grandchildren up all the time, I probably don't follow you, so I don't see you on my timeline, but it doesn't mean I don't like you :-)

I never got into Twitter in the same way, I guess I never really understood it. But yes, Facebook does it for me, and I'm glad it's around. As I travel the world now, I can take you all with me!

If you agree, please sign the petition at the end of this article...

It seems the Conservatives cannot wait to betray their most loyal voting group. If you are a pensioner – beware!

The Department for Work and Pensions appears to be planning to delete the cold weather payment from its chequebook, along with free bus passes and free TV licences.

We already know that the age at which the state pension will be paid is rising, meaning people will have to continue working for longer before they qualify for the £144/week payment (with a minimum National Insurance record of 30 full years). This is a betrayal of promises made by both the Conservatives and the Liberal Democrats in their document ‘The Coalition: Our Programme for Government’.

Because life expectancy depends on where you live and your social class, this means many poorer people will enjoy only three-to-six years of retirement on average, while richer pensioners get 17-20 years of pension payments. That’s right – rich people even get a better deal from the state pension.

Meanwhile, the taxpayer is being asked to fund three-fifths of the pension scheme for members of Parliament, who qualify at the age of 60 after 20 years’ service (or after 15 years if aged between 60 and 65) and receive an average of £353/week (see House of Commons Library SN6283: MPs’ Pension Scheme – 2012 onwards).

MPs (along with civil servants and judges) will receive transitional protection as the pensionable age rises – meaning they won’t lose out. More than 700,000 working women, on the other hand, have received less than two years’ notice of changes that will deprive them of up to £7,500 per year.

Iain Duncan Smith announced at yesterday’s meeting of the Commons Work and Pensions Committee that he was considering removing benefits that are exclusively for pensioners, in order to bolster his Benefit Cap.

He said: “We need maximum flexibility with the cap. Pretty much all existing ringfences will have to disappear.”

Asked if pensioner benefits would be included in the cap, he said: “These are matters which are still under discussion.”

The Benefit Cap was hailed as a hugely popular policy after its introduction last year, but it is now questionable whether pensioners will be quite so enthusiastic.

Including pensioners’ benefits among those that are capped means they may have to be means tested in the future, as the number of pensioners grows – putting pressure on the £200 billion benefits budget.

The Daily Mirror reported that Treasury sources played down this prospect last night, saying the annual spend on pensioner benefits was dwarfed by other payments. This is disingenuous as the annual spend on pensions is more than on all the other benefits combined. Cutting pensioner benefits and forcing people to work longer before they receive their pensions will deprive senior citizens of billions of pounds.

While changes to pensioners’ benefits are still under discussion, changes to the age at which pensions are paid have already become law.

The hypocrisy of MPs in imposing new rules that disadvantage ordinary people while protecting themselves, judges and civil servants has led to the creation of a petition on the 38 Degrees website, calling for the changes to be reversed.

The petition states: “It is discrimination to impose ‘rules’ that disadvantage one group of people more than another. It is against the law to treat someone less favourably than someone else. How can this Government be allowed to get away with this?

“Because of this broken promise those of us affected are now being forced to work longer and wait longer to receive our state pension, which is an entitlement and something to which we have contributed, all of our working lives.

“These changes will also have a detrimental impact upon employment opportunities for young people. The longer we are being forced to work, the fewer jobs there will be for them. Is this an honourable way to treat people?

“The right to retire with financial security, at the age that has been promised throughout our working lives, has been denied.

“This broken promise is unfair, unnecessary and totally unacceptable. Ministers need to do a u-turn on this mean-spirited move and honour their word.”

The petition currently (Dec 2nd 2014) has over 27,000 signatures. If you agree with it, please visit the 38 Degrees website and sign.

Me aged 15...

We all met at York station on 9th May, 1967 to catch the Harrogate train. Such different backgrounds, such very different people. Could we have guessed what the next 47 years would bring? 
Made my day to get this from Gary, hope we get a good turnout at the reunion next year.

Still trying to trace…

Edwin Dear (Southampton)
Gerard Vincent (Croesyceiliog)
Graham Hopper (Kent)
Gordon Lee (Sunderland)

If any of you happen to Google your names and end up here, please e-mail me at dansencier@yahoo.co.uk
Don't be afraid if you've come out as gay, bi-sexual or some other weird stuff, it couldn't be stranger than the lot we've got! Get in touch, please.

70,000 hits and growing fast….

Before the end of this week, the blog will clock over the 70,000 hits mark! 
Over 2,000,000 words and followed in countries all around the world…
Who do I know in Turkey? 

Some posts more popular than others… The 'Angel of Death' still in front, but  hey, if she hadn't refused to meet me, maybe the blog would have never started!

I keep getting badgered by Google to allow adverts on, but I choose to keep it clean of that stuff. It's a pleasure to keep it going knowing that so many follow. I often wonder what the very last posting will be! But for now, on this glorious summer day in South Africa, thank you all wherever you are for dropping in so often, and making my day!

New drug research for advanced prostate cancer...

Early results from drug trial reveal promising findings in men with advanced prostate cancer

• 05 Nov 2014
• In - Research | Prostate cancer in the media

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Yesterday at the NCRI (National Cancer Research Institute) cancer conference, Professor Johann De Bono revealed exciting new results from a clinical trial he’s leading for men with advanced prostate cancer. The trial, funded in part by Prostate Cancer UK and the Movember Foundation, is investigating the use of a drug called olaparib in men with advanced prostate cancer.

Olaparib is one of a class of drugs called PARP inhibitors. It is already licensed for use and very effective in treating ovarian cancer. PARP inhibitors work by cancelling out the effect of mutations in the genes responsible for repairing DNA when it gets damaged. In normal cells, damaged DNA is quickly repaired. But when the genes responsible for repairing the broken DNA are mutated, this damage goes unchecked. This can lead to errors in the DNA which can eventually cause cancer. PARP inhibitors work by killing cells with damaged DNA, so preventing tumour growth.

We already know that inheriting mutations in DNA damage repair genes, for example BRCA1 or BRCA2, can increase a man’s risk of developing advanced prostate cancer. But new research has shown that mutations in these genes can still develop over the course of advanced disease in men who didn’t inherit them. (This research also featured in a Prostate Cancer UK sponsored session at the NCRI cancer conference this week led by as discussed by Professor Karen Knudsen.)

That’s why Professor de Bono and his team at the Institute of Cancer Research and the Royal Marsden NHS Foundation Trust are testing olaparib in men without inherited mutations in DNA damage repair genes in a clinical trial called TO-PARP.  So far the results have been positive, with some patients with advanced, aggressive prostate cancer having an impressive response to the drug.

"Finding existing drugs that will work for prostate cancer alongside searching for new ones will speed up the process of getting treatment to the men who need it."

And new research published by Dr Gerhardt Attard, a colleague of Professor De Bono at the Institute of Cancer Research, has enabled researchers to take this trial even further. Thanks to Dr Attard’s team, it’s now possible for the researchers to test for mutations in DNA damage repair genes throughout the course of the disease. This means treatments like PARP inhibitors can be targeted to those patients who are most likely to respond, at the earliest possible time.

These are still very early results, so it’s too soon to say for certain that these treatments will definitely be beneficial, but it’s really exciting to see clinical trials investigating new uses for drugs that we already know work well for other cancer types. Finding existing drugs that will work for prostate cancer alongside searching for new ones will speed up the process of getting treatment to the men who need it enormously. And not a moment too soon.

• Tags: Finding answers, Treatment

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Prostate Cancer for beginners...

Basic Male Anatomy.  Photo © A.D.A.M.

  

Prostate Cancer Basics

Whether you or someone you know has been recently diagnosed with prostate cancer or you are simply interested in learning more about this important disease, there are three key questions that need to be answered.

What Is the Prostate?

The prostate is a small, walnut-sized gland that exists only in men. It is situated just below the bladder and just in front of the rectum in the lower pelvis.

The bladder acts as a storage area for urine. When the bladder is emptied, the urine travels through a thin tube called the urethra to the penis and then out. The very beginning of the urethra as it leaves the bladder passes directly through the prostate. This fact accounts for why so many men with either prostate cancer or BPH (benign prostatic hyperplasia) develop trouble urinating. As the prostate enlarges, the urethra is pinched off, leaving a smaller tube to carry urine from the bladder to outside the body.

The prostate’s primary function is to produce much of the fluid that makes up semen. Semen acts to protect sperm as it makes its way out of the body.

The prostate is present from before birth and grows in response to male hormones such as testosterone. Blocking the production or effects of these hormones is one of the primary treatment options for prostate cancer.

What Is Cancer?

Cancer is most simply explained as cells in a certain part of the body that have started to grow in an out-of-control and unregulated fashion.

The human body is made up of billions of tiny units called cells. These are the smallest structures in the body that can be considered to be living. They can only be seen under high-powered microscopes. Cells normally go through a life cycle of growth, division, and death. When this occurs in an orderly fashion, cells are created and die in roughly equal numbers. They also normally stay confined to the area of the body in which they were meant to be.

Unfortunately, certain cells sometimes begin to multiply much faster than they die. When this happens, these abnormal cells squeeze out nearby normal cells. These abnormal cancerous cells can also spread outside of their original site in the body and spread to other areas. When cancer from one body site has spread to other areas of the body, the cancer can be said to have “metastasized". This is always an unfortunate occurrence as cancer that has spread is much harder to treat in general.

A cancer is named after its original site in the body. For example, prostate cancer, even if it were to spread to the bones or to the colon would still be called prostate cancer and not bone or colon cancer. This would more appropriately be called “prostate cancer with metastasis to the bone.”

All types of cancer are different. For example, prostate cancer is very different from lung cancer. The two are caused by different factors, diagnosed in different ways, and treated differently. Regardless of the type of cancer, the underlying problem is the unregulated and abnormal growth of the cells in that part of the body.

What Is Prostate Cancer?

Since cancer is the uncontrolled and abnormal growth of cells in a certain area of the body, prostate cancer is simply the uncontrolled and abnormal growth of cells in the prostate.

Some men have BPH (benign prostatic hyperplasia). This is often confused with prostate cancer. With BPH, prostate cells multiply faster than they should. This causes the prostate to enlarge and the patient to develop difficulty urinating. With prostate cancer, the cells not only multiply faster, but also behave abnormally by spreading outside of the prostate if not caught in time. BPH is not cancer, but can show some of the same symptoms.

The prostate is made up of many different types of cells. The gland cells (those cells that actually work to produce the fluid that is released into the semen) however, are nearly always the cells that become cancerous. The technical medical term for cancer that arises from gland cells is adenocarcinoma. Thus, the technical term for prostate cancer is prostate (or prostatic) adenocarcinoma.

Early detection, prompt diagnosis, and effective treatment are the mainstays of good prostate cancer care.